About genetics:
There are three possible genotypes: if the dog is free (N/N) he has only the normal alleles and does not get PRA. If teh dog is a carrier (N/PRA) he has one mutant and one normal allele; so, he has a low risk to get PRA because the disease is recessive but he passes the mutant allele to its offspring with a probability of 50%. Therefore this dog should only be mated to a free dog to avoid the "development" of affected dogs. If you mate two carriers, you will get 25% clear, 50% carriers and 25% affected dogs. This is statistics!!! So, it is possible you have only free dogs in a litter or only affected. Affected dogs (PRA/PRA) have two mutant alleles and have a high risk to get PRA.
I hope this will help you. For further questions do not hesitate to mail again.
Best regards,
Alexandra Kehl, Dipl. Biol.
Molekularbiologie
JA TASSA BOMBIX MOREN AMRON´S TOPCOPYN TESTI TULOS.
OHESSA OTE TUTKIMUSTULOKSESTA :
patient identification:dog Australian Silky Terrier
male
date sample was taken: 25-07-2007
owner /animal ID: Leino, Irma
type of sample: EDTA-blood
sample ID: 0708-S-00785
parameter value reference value
Name: "Bombix Moren Amron's Topcopy"
PRA-Gentest
Result: genotype N/N
Interpretation: The analysed dog is noncarrier of the mutation
in the PRCD-gene and will not develop the prcd-form of PRA.
Since it cannot pass the mutation onto its offspring,
it can be mated to any other dog.This result is only valid for the submitted sample material.
stud book no. FIN 46532/02
chip no. 246098100143010
tatoo no. M6532C
The lab is accredited according to DIN ISO 17025 for the services
mentioned above.
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